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KMID : 0376419890130030229
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Chonbuk University Medical Journal
1989 Volume.13 No. 3 p.229 ~ p.239
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clinical studies of nephrotic syndrome in children
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Abstract
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The author reviewed 72 cases of idiopathic nephrotic syndrome who were admitted to the pediatric department of Chonbuk National University Hospital during last 10 years.
The following results were observed.
1) Age and sex distribution.
The most common age group was between 3 and 5 years of age.
Male to female ratio was 7:1.
2) Duration of illness before admission.
50 patients (69.4%) were admitted within 6 months of illness.
3) Clinical manifestations.
Generalized edema (72.2%), ascites (47.2%), and gastrointestinal disturbance (31.9%) were major clinical manifestations.
4) Onset of diuresis after steroid therapy.
In 37 patients (51.4%), diuresis was occurred within first one week after steroid therapy. 5) Disappearance of proteinuria after steroid therapy.
Within first two weeks after steroid therapy, proteinuria was disappeared in 38 patients (52.7). 6) Response to initial steroid therapy.
Among 72 patients who recieved initial continuous steroid therapy, 44 patients (61.1%) were in complete remission group, 16 patients (22.2%) were in partial response group and 12 patients (16.7 %) were in poor response group.
7) Relationship berween steroid response and nephritis symptoms.
Hematuria, hypertension and elevated serum creatnine were more frequently observed in partial and poor response group than in complete remission group.
8) Frequency of relapses during first one year.
Among 20 patients who were follow up over one year after steroid therapy, 15 patients were relapsed within first one year after steroid therapy.
9) Response to immunosuppressant therapy.
Cyclophosphamide therapy were effective in 15 of 20 patients who recieved cyclophosphamide therapy with steroid therapy.
10) Histopathological findings.
Most common finding was minimal change (48%).
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KEYWORD
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Nephrotic syndrome, Children, Clinical studies
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